Cellulose nanocrystals/zinc oxide nanoparticles for Enhanced Antifungal Activity and Flexural Properties of a Heat-cured Acrylic Denture Base Material.

Document Type : Original Article

Authors

1 Dental Biomaterials, Faculty of Dentistry, October 6 University, Cairo, Egypt

2 Pharmacognosy Department, Faculty of Pharmacy, Mansoura University, Egypt

3 Biomaterials Department, Faculty of Dentistry, Cairo University, Egypt

10.21608/adjc.2024.343170.1677

Abstract

Abstract
Aim: To develop an antifungal heat-cured acrylic denture base material with enhanced flexural strength, by incorporating a nanohybrid of nanocellulose and nano zinc oxide into the acrylic.
Methodology: Zn2+ was precipitated on the surface of nanocellulose to create a nanohybrid of nanocellulose and nano zinc oxide. The nano zinc oxide, nanocellulose, and nanohybrid were evaluated for particle size and surface morphology using transmission and scanning electron microscopy respectively, and their structure was determined using X-ray diffraction. Two groups of specimens were prepared: unmodified conventional acrylic resin (control), and 1.1% w/w nanohybrid-modified acrylic (intervention). In each group, nine cylindrical specimens were prepared to evaluate antifungal activity using agar dilution method, and eleven bar-shaped specimens for determination of three-point flexural strength and modulus using a Universal Testing Machine.
Results: In 1/10 and 1/100 dilutions, incorporating the nanohybrid into the conventional heat-cured acrylic significantly reduced Candida colonies count and led to a notable improvement in both flexural strength (93.38 ± 7.34 MPa for the modified vs. 44.89 ± 4.06 MPa for the unmodified group) and modulus (2257.78 ± 168.37 MPa for the modified vs. 1373.26 ± 209.69 MPa for the unmodified group).
Conclusions: Incorporating 1.1% w/w of the nanohybrid into conventional heat-cured acrylic resin may be considered a viable approach to provide antifungal activity and enhance flexural strength and modulus.

Keywords

Main Subjects

Files

Share

How to cite

Statistics