Immunohistochemical Expression of EBP50 Protein in Oral Lichen Planus: A Retrospective Cross-Sectional Study

Document Type : Original Article

Authors

1 Oral Pathology Department, Faculty of Dentistry, the British University in Egypt.

2 Oral and Maxillofacial Pathology, Faculty of Dentistry, Cairo University.

Abstract

Aim: The goal of this study is to investigate how the Na+/H+ Exchanger Regulatory Factor-1/Ezrin-radixin-moesin-binding phosphoprotein 50 protein is expressed in Oral Lichen Planus using immunohistochemistry.
Subjects and methods: This will be accomplished by gathering archival blocks of normal oral epithelium (control group) and oral lichen planus, applying the marker to the specimens, and subsequently quantifying the expression location, area percentage, and nuclear expression.
Results: The control group showed negative expression in basal cells, cytoplasmic in parabasal cells, membranous in spinous cells, and gradually disappeared in superficial cells until it became negative in the cornified layer. All oral lichen planus cases showed cytoplasmically positive basal cells, with sixty-four percent of them displaying prickle cell nuclear positivity and perinuclear cytoplasmic staining.
Conclusion: There was a significant difference in the marker’s expression between the tested groups. This is owing to its different functions depending on its expression location and the type of tissue.

Keywords

Main Subjects

Advanced Dental Journal
Volume 7, Issue 3
July 2025
Pages 555-562

Files

Share

How to cite

Statistics