Silk Fibroin Nanofiber Membrane Using Minimally Invasive Surgical Technique in Management of Grade II Furcation Involvement: A Randomized Clinical Trial

Abd El Aziz, Nada; Gaber Ealamy, Dalia Shawky; Mohamed Abbas, Hisham; Kheir El Din, Nevine H.; Youssef Gamal, Ahmed; Lotfy Aggour, Reham

doi:10.21608/adjc.2025.360531.1701

Silk Fibroin Nanofiber Membrane Using Minimally Invasive Surgical Technique in Management of Grade II Furcation Involvement: A Randomized Clinical Trial

Document Type : Original Article

Authors

¹ Department of Oral Medicine and Periodontology, Faculty of Dentistry, October 6 University, Egypt

² Department of Oral Medicine and Periodontology, Faculty of Dentistry, Egyptian Russian University, Egypt

³ Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Cairo University, Egypt Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, October 6 University, Egypt

⁴ Department of Oral Medicine and Periodontology, Faculty of Dentistry, Ain-Shams University, Egypt

⁵ Department of Oral Medicine and Periodontology, Faculty of Dentistry, Ain-Shams University, Egypt Department of Oral Medicine and Periodontology, Faculty of Dentistry, Misr University for science and technology, Egypt

10.21608/adjc.2025.360531.1701

Abstract

Abstract
Objectives: To investigate the clinical and radiographic outcome of the regenerative treatment of molars with grade II furcation involvement (FI) using minimally invasive surgical technique (MIST) with silk fibroin (SF) membrane in comparison to MIST. The research is planned as a prospective, controlled, single-blind, randomized clinical experiment.
Patients and methods: A total of twenty patients with Grade II FI were randomly assigned to two groups; Group I: MIST (n=10); Group II: MIST+ SF membrane (n=10). Clinical (Clinical Attachment Level [CAL], Probing Pocket Depth [PD], Plaque Index [PI] and Gingival index [GI]) and radiographic (filled bone volume [FBV]) parameters were evaluated at baseline and 6 months postsurgical. FBV was the primary outcome.
Results: For both groups, a statistically significant improvement was reported for CAL (1.63 ± 1.02, 2.75 ± 0.65), PD (1.63 ± 0.68, 2.25 ± 0.47) and FBV (0.02 ± 0.07, 0.056 ± 0.062) for control and test group respectively, at 6 months evaluation period. There was an insignificant difference between the study groups.
Conclusions: The addition of SF membrane to MIST improve clinical and radiographic outcomes when treating molars with degree II FI, however, this improvement was statistically insignificant.

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