Solitary Fibrous Tumor: A Case with a Review

Document Type : Case Reports


1 Assistant Lecturer of Oral Pathology Cairo, Egypt

2 Department of oral and maxillofacial pathology, Faculty of dentistry, Cairo university, Cairo, Egypt.

3 Oral and Maxillofacial Pathology, Faculty of Dentistry, Cairo University, Cairo, Egypt. Oral and Maxillofacial Pathology, Faculty of Dentistry, NewGiza University, Giza, Egypt.


solitary fibrous tumor (SFT) is a rare intraoral occurring tumor. Buccal mucosa is among the most commonly affected sites. SFT lesions are linked to a NAB2-STAT6 fusion gene. The lesion exhibits well circumscribed feature in both radiographical and histopathological examinations. The lesion shows STAT 6, CD34, bcl-2 and CD99 positive expression. Unfortunately STAT6 and CD 34 expression are lost in highly malignant lesions, making the diagnosis challenging. The reported case is a 43 –year- old female presented with a painful lesion in the left buccal mucosa. Upon surgical excision and histopathological examination the lesion revealed a bland spindle cell lesion with nuclear STAT6 and beta catenin cytoplasmic reactivity. After excision the case was followed up for 6 months and showed no recurrence. This case showed a typical presentation the same as the literature reported cases. However, the associated pain was coming in contrast to the most published cases. Although being usually negative in SFT, beta catenin showed cytoplasmic reactivity in our presented case.


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