Association between GCF Sclerostin Level and Haemoglobin A1c in Stage III Periodontitis Patients with Controlled and Uncontrolled Type 2 Diabetes Mellitus: A Case-Control Study

Document Type : Original Article

Authors

1 Oral Medicine and Periodontology Department, Egyptian Russian University, Cairo, Egypt.

2 Oral Medicine and Periodontology Department, Faculty of Dentistry, Beni-Suef University, Beni-Suef, Egypt.

Abstract

Aim: The aim of this study was to investigate the association between sclerostin level in gingival crevicular fluid and glycosylated haemoglobin in stage III periodontitis in non-diabetic, controlled and uncontrolled diabetic patients. Methods: 36 patients were included in this study. They were diagnosed as stage III periodontitis according to new classification of periodontal and peri-implant diseases diseases 2017. Patients were categorized into three groups with 12 patients for each group; group I (non -diabetic), group II (controlled diabetic) and group III (uncontrolled diabetic patients). Gingival crevicular fluid samples were collected from the site with greatest clinical attachment loss of each patient and sclerostin concentration was assessed by enzyme-linked immunosorbent assay.  Results: There was no significant difference between sclerostin concentration in gingival crevicular fluid of three groups with highest concentration was in controlled diabetic patients. Also, there was no association between sclerostin concentration in gingival crevicular fluid and glycosylated haemoglobin in all study groups.  Conclusion: Periodontitis was suggested to have more effect on sclerostin level than diabetes mellitus, which augment the evidence of sclerostin role in periodontitis destruction and recommended the anti-sclerostin antibody as a promising treatment for periodontitis.

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Advanced Dental Journal
Volume 5, Issue 4
October 2023
Pages 910-918

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