The Efficacy of Topical Sesame Oil in Orabase Versus Topical Triamcinolone in Orabase on Oral Lichen Planus and Salivary Level Of Oxidative Stress Biomarker (MDA): Randomized Clinical Trial

Mohammed, Mona Taha; Azab, Noha Adel; Shaker, Olfat Gamil; Hussine, Amal Ali

doi:10.21608/adjc.2023.216208.1336

The Efficacy of Topical Sesame Oil in Orabase Versus Topical Triamcinolone in Orabase on Oral Lichen Planus and Salivary Level Of Oxidative Stress Biomarker (MDA): Randomized Clinical Trial

Document Type : Original Article

Authors

¹ Oral Medicine and Periodontology Department, Faculty of Dentistry, Cairo University, Egypt.

² Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Egypt.

10.21608/adjc.2023.216208.1336

Abstract

Objectives: To compare the effectiveness of topical sesame oil in the formulation of a gel and topical triamcinolone acetonide 0.1% in dealing with the signs and symptoms of OLP. Patients and Methods: This randomized, controlled trial had thirty four patients who were randomly allocated to receive either sesame oil gel or triamcinolone acetonide 0.1% gel thrice daily for 4 weeks. We assessed pain using the visual analogue scale and erythema and ulceration using the Thongprasom score and salivary MDA by ELISA. Results: Patients improved significantly in both groups, however change in the triamcinolone group occurred significantly faster than the sesame oil group. The Thongprasom score differed significantly between both groups (p< 0.001) favoring the triamcinolone group. The MDA level was statistically insignificant between both groups. Conclusion: Sesame oil can relieve pain but not as quickly as triamcinolone acetonide, additionally, it has no detectable effect on improving the clinical picture of OLP.

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