The Efficacy of Topical Sesame Oil in Orabase Versus Topical Triamcinolone in Orabase on Oral Lichen Planus and Salivary Level Of Oxidative Stress Biomarker (MDA): Randomized Clinical Trial

Document Type : Original Article


1 Oral Medicine and Periodontology Department, Faculty of Dentistry, Cairo University, Egypt.

2 Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Egypt.


Objectives: To compare the efficacy of topical sesame oil in the formulation of gel and topical triamcinolone acetonide 0.1% in managing the signs and symptoms of OLP. Patients and Methods: This randomized, non-blind, controlled trial had thirty four patients who were randomized into two groups to receive either sesame oil oral gel or triamcinolone acetonide 0.1% oral gel thrice daily for 4 weeks.  The patients were analyzed for the symptom (burning) using visual analogue scale and sign (erythema and ulceration) using the thongprasome index and salivary MDA by ELISA technique.  Results: The VAS scores was statistically significant between both groups (p =0.003). The Thongprasome index was statistically significant between both groups (p< 0.001); The MDA was statistically insignificant between both groups (p= 0.838). Our analyses demonstrated statistically.  Conclusion:  Sesame oil has no detectable effect on improving the clinical picture of OLP. It had an inferior effect to triamcinolone in relieving pain and clinical picture.


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