Adverse Effects of Application of Fluoride Varnish versus Resin-Based Fissure Sealant in Newly Erupted Permanent Molars in Group of Egyptian Children: A Randomized Clinical Trial

Document Type : Original Article


1 Pediatric Dentistry Department, Faculty of Dentistry, Cairo University, Egypt

2 Pediatric Dentistry and Dental Public Health Department, Faculty of Dentistry, Cairo University, Egypt


This study aims to determine the adverse effects of fluoride varnish (FV) versus resin-based fissure sealant (RBS) required to prevent caries in newly erupted permanent molars in a group of Egyptian children. methods: This is a randomized clinical trial with two arms, parallel groups, and allocation-blinded. The total number of participants was 91, with ages ranging from 6 to 8 years. The participants were randomly assigned to one of two groups: RBS as a control and FV as an intervention. (45) teeth were in the FV group, and (46) teeth were in the RBS group. Of the 91
teeth only 89 teeth completed the follow-up at 6 and 12 months. The findings measured were the adverse effects of FV & RBS using a custom-made questionnaire for the parent and visually at the clinic.
Results: At this study 91 teeth were randomly allocated to both tested groups. There were 28
(56.0%) males and 18 (43.9%) females in the FV group, while in the FS group there were 22
(44.0%) males and 23(56.1%) females. The mean age in the FV was (7.00±1.12) years, while in
FS it was (7.29±1.42) years. There was no significant difference between both groups regarding
demographic data (p>0.05). The results showed that there were no adverse effects in both groups.
Conclusion: Based on the 12 months results the two preventive methods are recommended to be
used in prevention of dental caries. Furthermore, FV was not statistically inferior to FS. The two preventive methods had no adverse effects