Evaluation of Urinary Insulin Like Growth Factor-1 as a Maturation Indicator in Females: A Cross-Sectional Study

Document Type : Original Article


Orthodontics Department, Faculty of Dentistry, Cairo University, Egypt


Aim: the current study was adopted to assess the pubertal growth spurt by evaluating the urinary insulin-like growth factor 1 (UIGF-1) in Egyptian females and estimate the mean chronological age at the peak of urinary IGF-1. Methodology: A total sample of 48 subjects was recruited from the Orthodontic Department of the Faculty of Dentistry- Cairo university. They were equally divided (N=16) into three age ranges (8-10), (10 -12) and (12 - 14). Lateral cephalograms were taken from the subjects for cervical vertebral assessment according to Baccetti et al. and assessed twice by the same rater with a one-week interval and one assessment by another rater. Fresh morning urine samples were collected from subjects to quantify the concentration of IGF-1 by ELIZA technique. Results: A compatibility and correlation between the UIGF-1 and CVM and between UIGF-1 and age subgroups was statistically analyzed in females. From the UIGF-1 curve, it was shown that the peak of UIGF-1 at CVM 4, which was significantly different from the mean values of other CVM stages (P ˂0.05). Females reachd the peak UIGF-1 value at 12.42 years. UIGF-1 at CVM 3 preceded the CVM 4 representing the onset of a growth spurt with the mean age of 11.29 years in females. Conclusion: UIGF-1 is compatible with the CVM stages. A significant positive moderate correlation was found between UIGF-1 and CVM, and between UIGF-1 and chronological age. Thus, it is a reliable biological indicator employed in orthodontics for growth spurt assessment.