Cairo University, Faculty of Dentistry
Advanced Dental Journal
2636-302X
2636-3038
2
1
2020
01
01
Evaluation of Topical Pomegranate Extracts in Management of Oral Lichen Planus: A randomized clinical trial
1
11
EN
Mai
Zakaria
0000-0002-2846-6094
Oral Medicine and Periodontology Department, Faculty of Dentistry, Cairo University, Egypt
mai.zakaria@dentistry.cu.edu.eg
Ataa
Said
Pharmacognosy Department, Pharmaceutical Sciences Division, National Research Centre, Cairo, Egypt
ataasaid@yahoo.com
Amal
Abd EL-Kader
Chemical Engineering and Pilot Plant Dep. National Research Centre, Cairo, Egypt
amalibrahim67@yahoo.com
Basma
Mostafa
Surgery and Oral Medicine Dep., Oral and Dental Research Division, National Research Centre, Cairo, Egypt
boshta@hotmail.com
10.21608/adjc.2020.22381.1047
<strong>Background:</strong> The current study aimed to evaluate the effect of using topical pomegranate extracts gel versus topical steroid gel as a control in management of atrophic oral lichen planus (OLP). <br /> <strong>Materials and methods:</strong> Forty-two patients presenting clinically with atrophic OLP were involved in the study. They were randomly divided into three equivalent groups to be managed with topical corticosteroid gel as control (Group 1, Group C), topical pomegranate seed extract gel (Group 2, Group S) and topical pomegranate peel extract gel (Group 3, Group P). Assessment of pain, sign scores and oral health impact profile- 14 (OHIP- 14) were carried out in each group before and after the used management protocols. <br /> <strong>Results:</strong> The results showed a significant decrease in sign; pain scores and OHIP-14 values which were recorded in group S and group P. <br /> <strong>Conclusion:</strong> Provided data in this contemplate using topical pomegranate seeds and peel extracts gel offer a new promising natural, safe and effective management of OLP.
extracts,peel,OHIP-14,Oral lichen planus,Pain,Punica granatum L
https://adjc.journals.ekb.eg/article_68490.html
https://adjc.journals.ekb.eg/article_68490_11d11837afa1cdc0305c875a636660af.pdf
Cairo University, Faculty of Dentistry
Advanced Dental Journal
2636-302X
2636-3038
2
1
2020
01
01
Evaluation of the Effect of Solcoseryl on Promotion of Bone Regeneration in Calvarial Bony Defect – An Experimental Pilot study
12
23
EN
Alaa
Reda Ibrahim
El-Sayyad
Oral and Maxillofacial Surgery Department Faculty of Dentistry, Cairo University. Cairo, Egypt.
lolo.rere1988@gmail.com
Tarek
Ibrahim
Elghareeb
Associate Professor of Oral and Maxillofacial Surgery Faculty of Dentistry, Cairo University, Cairo, Egypt.
t_ghareeb@hotmail.com
Mohammed
Mokhtar
Khashaba
Associate Professor of Oral and Maxillofacial Surgery Faculty of Dentistry, Cairo University, Cairo, Egypt.
mohammedkhashaba@hotmail.com
Mohammed
Ahmed
Zayed
Associate Professor & the Head of Division of Oral Biology Department, Faculty of Dentistry, Misr International University, Cairo, Egypt.
drzayed2@gmail.com
10.21608/adjc.2020.21066.1040
<strong>Aim:</strong> To evaluate the effectiveness of Solcoseryl on bone regeneration in rabbit calvarial bony defect through histological examination and histomorphometric analysis.<br /> <strong>Materials and Methods:</strong> Twenty New Zealand rabbits were divided into 4 groups. Two cavities were drilled in the calvarial bone of each rabbit. Defects were left empty in group A as a control group or filled with either Solcoseryl in group B, DM Bone in group C or (Solcoseryl & DM Bone) mixture in group D. Rabbits were sacrificed on day 14; the defects were removed and prepared for histological and histomorphometric analysis. The area percent of newly formed bone was estimated. Comparison of the results of all groups were statistically analyzed by ANOVA and Post-hoc tests.<br /> <strong>Results:</strong> Histological evaluation revealed presence of granulation tissues in control group while woven bone formation was evident in all experimental groups with evident osteoid tissue in group C & D. Histomorphometric analysis revealed that the quantity of newly formed bone was the greatest in mixture group. The greatest area percent of uncalcified bone was recorded in control.<br /> <strong>Conclusion:</strong> Combination of Solcoseryl and DM Bone has a synergistic effect on bone formation quantitatively and qualitatively.
bone regeneration,β-TCP,HA,Scaffold,Solcoseryl
https://adjc.journals.ekb.eg/article_68493.html
https://adjc.journals.ekb.eg/article_68493_6ba4037d7826f6fa84866873f4a448e3.pdf
Cairo University, Faculty of Dentistry
Advanced Dental Journal
2636-302X
2636-3038
2
1
2020
01
01
Effect of adjunctive systemic vitamin E on clinical parameters and salivary total antioxidant capacity in symptomatic oral lichen planus patients: Randomized controlled clinical trial
24
33
EN
Engy
Abdeldayem
0000-0002-1338-2891
oral medicine and periodontology,faculty of dentistry,cairo university,cairo,Egypt
engyabdeldayem@hotmail.com
Wesam
Abdel Moneim
Mohamad
Oral Medicine and Periodontology, Faculty of Dentistry, Cairo University,cairo, Egypt
wesammhs@yahoo.com
Olfat
Gamil
Shaker
0000000230313599
Department of Biochemistry, Faculty of Medicine, Cairo University,Cairo,Egypt
olfatshaker@yahoo.com
Shereen
Ali
0000-0003-3794-2491
oral medicine and periodontology,faculty of dentistry,cairo univeristy,cairo,egypt
cherriesah@hotmail.com
10.21608/adjc.2020.22386.1046
<strong>Background:</strong> Most of the available therapeutics of oral lichen planus are associated with adverse effects and there is no sufficient evidence to support the effectiveness of these modalities over placebo or over each other. Micronutrients including antioxidants modify the immune system function and are considered promising alternatives in management of OLP with negligible side effects. The current trial assessed the effect of adjunctive use of systemic vitamin E in symptomatic oral lichen planus patients.<br /> <strong>Methods:</strong> This randomized controlled clinical trial includes 30 symptomatic (erosive and atrophic) oral lichen planus patients in two parallel groups (intervention – topical triamcinolone acetonide adhesive paste and Vitamin E, control - topical triamcinolone acetonide adhesive paste and placebo), with allocation ratio 1:1. Outcome measures were pain intensity, clinical improvement and salivary level of total antioxidant capacity.<br /> <strong>Results:</strong> Mean amount of pain reduction and clinical improvement were greater in the experimental group with statistically significant difference. Mean amount of total antioxidant capacity upregulation was greater in the control group with no statistical difference.<br /> <strong>Conclusion:</strong> Adjunctive use of systemic vitamin E has shown promising results in management of OLP with no side effects.<br /><br />
Vitamin E,Oral lichen planus,salivary total antioxidant capacity,Randomized-controlled clinical trial
https://adjc.journals.ekb.eg/article_68508.html
https://adjc.journals.ekb.eg/article_68508_dc299a330648bda74dafcc0179bb38f9.pdf